Zinc supplementation may reduce the minimum effective dose of amphetamine when it is used for the treatment of ADHD.
2.
This is generally defined by the range between the minimum effective dose ( MED ) and the maximum tolerated dose ( MTD ).
3.
Following 4 week oral repeat dosing in the DIO mice, gemigliptin reduced significantly HbA1c with the minimum effective dose of 3 mg / kg.
4.
In a 321-page " medical officer review " dated Nov . 9, 1987, he described the proposed 10-milligram dose of Claritin as " minimally effective vs . placebo " and added that 40 milligrams appeared to be " the minimum effective dose ."
5.
The U . S . Department of Health and Human Services restated these two years later as " The downward KI ( potassium iodide ) dose adjustment by age group, based on body size considerations, adheres to the principle of minimum effective dose.
6.
In the diet-induced obese ( DIO ) mice, gemigliptin reduced glucose excursion during OGTT in a dose dependent manner with the minimum effective dose of 0.3 mg / kg and enhanced glucose-stimulated plasma GLP-1 increase in a dose dependent manner reaching the maximum effect at the dose of 1 mg / kg.
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